Gray Matter Reduction in Hippocampal Subfields and associated auditory verbal learning and memory Decline with Ageing

Motivation: Assessing gray matter volume changes in hippocampal subfields will be help to elucidate the underlying mechanisms of age-related cognitive decline. Goal(s): To assess age-related changes in hippocampal subfield and their associations with Learning and memory performance in the healthy urban Indian population. Approach: To assess age related atrophy in hippocampal subfield. High-resolution 3D T1 images were acquired seventy-six participants, and divided into three groups based on age. Hippocampal subfield segmentation was performed using FreeSurfer. Results: Reduced volume of CA1, CA4, subiculum, pre subiculum, Para subiculum, molecular layer HP body, fimbria head, granule cell and molecular layer of the dentate gyrus (GC-ML-DG) with aging. Impact: Decreased hippocampus subfield volume maybe associated with deficits Auditory Verbal Learning (AVL); AVL-Immediate and Delay Recall Memory.