The Association of the Glymphatic Function with amyloid deposition: a clinical stage-specific Approach

Motivation: Glymphatic dysfunction may contribute to Alzheimer's pathology by impairing the clearance of amyloid β, leading to its accumulation. Goal(s): This study aims to investigate whether the ALPS index, a DTI-based measure of glymphatic function, correlates with amyloid β deposition. Approach: ALPS index values and amyloid β deposits were examined in cognitively normal and impaired older adults, with adjustments for age, sex, APOE ε4 status, and white natter hyperintensity volume. Results: The ALPS index was significantly lower in cognitively impaired group and inversely correlated with amyloid β deposition in the cognitively normal group. Impact: These findings suggest the ALPS index as a potential early biomarker for Alzheimer's, highlighting glymphatic dysfunction's role.