Simultaneous zero echo time fMRI of rat brain and spinal cord
Motivation: Currently fMRI focuses on either brain or spinal cord but rarely both. This is due to the demand of homogenous magnetic field over a large FOV. A comprehensive evaluation of central nervous system from distant sites would be crucial in many disorders that encompass both the brain and the spinal cord. Goal(s): To robustly detect fMRI responses simultaneously in rat brain and lumbar spinal cord. Approach: We utilized zero echo time MB-SWIFT fMRI sequence with dual-FOV approach. Results: We detected robust activations during hind limb stimulation in relevant areas of brain and spinal cord at individual and group level. Impact: The dual-FOV zero echo time sequence enables more comprehensive evaluation of central nervous system function and reorganization in different diseases or disorders such as pain and spinal cord injury.
Authors
- Gregor Adriany (ORCID: https://orcid.org/0000-0002-6428-9005)
- Jaakko Paasonen (ORCID: https://orcid.org/0000-0002-1529-596X)
- Russell Lagore (ORCID: https://orcid.org/0000-0003-1950-1828)
- Djaudat Idiyatullin (ORCID: https://orcid.org/0000-0002-0942-3208)
- Shalom Michaeli (ORCID: https://orcid.org/0000-0001-5426-8369)
- Lance DelaBarre
- Raimo A. Salo (ORCID: https://orcid.org/0000-0003-3610-236X)
- Hanne Laakso (ORCID: https://orcid.org/0000-0003-1142-9008)
- Olli Gröhn (ORCID: https://orcid.org/0000-0003-1372-1651)
- Mikko I. Kettunen (ORCID: https://orcid.org/0000-0002-2004-660X)
- Ekaterina Paasonen (ORCID: https://orcid.org/0000-0003-2365-865X)
- Dee M. Koski
- Sara Ponticorvo (ORCID: https://orcid.org/0000-0002-7933-1608)
- Silvia Mangia (ORCID: https://orcid.org/0000-0001-6341-4516)
- Lin Wu (ORCID: https://orcid.org/0000-0001-7169-3519)
- Ethan Polcyn
- Javier Istúriz
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0657
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00