Mean apparent propagator and neurite orientation dispersion and density imaging in distinguishing glioblastomas from solitary brain metastase

Motivation: Differentiating glioblastomas (GBMs) from solitary brain metastases (SBMs) is challenging due to similar MRI appearances, complicating treatment decisions. Advanced diffusion MRI techniques could enhance diagnostic accuracy. Goal(s): This study aims to assess the effectiveness of MAP-MRI and NODDI diffusion parameters, particularly the Orientation Dispersion Index (ODI), in distinguishing GBMs from SBMs. Approach: We conducted MRI on 43 patients with confirmed GBMs or SBMs, analyzing MAP-MRI and NODDI parameters, with a focus on NODDI_ODI's diagnostic performance. Results: NODDI_ODI showed high diagnostic accurac, with further improvement in the combined model of MAP_QIV, MAP_NGRad, and NODDI_ODI. Impact: MAP-MRI and NODDI offer diagnostic value in distinguishing GBMs from SBMs, with NODDI_ODI emerging as an effective imaging marker. Combined models show promise as sensitive biomarkers in neuro-oncology, potentially enhancing treatment strategies for GBMs and SBMs.