Myelin Water Fraction Orientation Dependence: An Ex-Vivo 9.4T Human Spinal Cord Study
Motivation: Recent in-vivo human and ex-vivo animal tissue research suggests that the Myelin Water Fraction (MWF) may depend on the angle of fibers relative to the main magnetic field. Goal(s): To investigate MWF orientation dependence in human spinal cord tissue. Approach: 9.4T multi-echo T2 relaxation data was collected from ex-vivo human spinal cord tissue rotated compared to B0. MWF in white matter was compared between 9 different angles. Results: MWF varied with orientation. The average COV of mean white matter (WM) MWF across 4 samples was 12.9%. Most samples had a consistent WM MWF vs. angle pattern. Impact: We observed variations in myelin water fraction (MWF) at different cord orientations relative to the B0 field, suggesting that MWF is dependent on fiber orientation. Further work should focus on methods to correct for orientation dependence when scanning in-vivo.
Authors
- Cornelia Laule (ORCID: https://orcid.org/0000-0002-9785-6918)
- Kirsten Bale
- Adam Velenosi
- Brian K. Kwon (ORCID: https://orcid.org/0000-0002-5089-8280)
- Sarah Morris (ORCID: https://orcid.org/0000-0003-2256-5654)
- Irene M. Vavasour (ORCID: https://orcid.org/0000-0001-9286-0953)
- Veronica Hirsch‐Reinshagen (ORCID: https://orcid.org/0000-0003-0530-871X)
- Andrew Yung (ORCID: https://orcid.org/0000-0002-9504-6794)
- Femke Streijger (ORCID: https://orcid.org/0000-0001-6343-8307)
- Pushwant Mattu
- Piotr Kozłowski (ORCID: https://orcid.org/0000-0002-6462-2891)
- Kevin Dong (ORCID: https://orcid.org/0009-0004-9090-1976)
- Lisa Parker
- George R. Moore
- Tigris Joseph
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/3542
- Primary Topic
- Balance, Gait, and Falls Prevention
- Type
- article
- Field-Weighted Citation Impact
- 0.00