Simultaneous T1 and T2 mapping of the brain at 7 Tesla with optimized and accelerated QuantoRAGE
Motivation: T1 and T2 relaxometry may provide valuable information for early detection and characterization of pathology at UHF but requires long scan times for large coverage and high-resolution. Goal(s): To enable fast simultaneous T1 and T2 mapping at 7T for the whole brain. Approach: The accelerated QuantoRAGE sequence used two scans with various T2 preparations and inversion times that were optimized using Cramér-Rao lower bound. A dictionary fitting model was then employed for T1 and T2 quantification. Results: QuantoRAGE showed feasibility for high-resolution T1 and T2 mapping in <7 minutes and provided values in good agreement with reference methods in phantom and healthy brains. Impact: QuantoRAGE allows for simultaneous T1 and T2 mapping of the whole brain at ultra-high field with high isotropic resolution and in less than 7 minutes, bringing quantitative MRI closer to clinical UHF applications.
Authors
- Tom Hilbert (ORCID: https://orcid.org/0000-0001-8207-4908)
- Berk Açıkgöz
- Jessica Bastiaansen (ORCID: https://orcid.org/0000-0002-5485-1308)
- Dominik M. Nickel (ORCID: https://orcid.org/0000-0002-0360-7233)
- José P. Marques (ORCID: https://orcid.org/0000-0001-8157-8864)
- Bénédicte Maréchal (ORCID: https://orcid.org/0000-0001-7866-2854)
- T. D. Nguyen (ORCID: https://orcid.org/0000-0002-3862-5853)
- Gabriele Bonanno (ORCID: https://orcid.org/0000-0003-4115-7963)
- Piotr Radojewski (ORCID: https://orcid.org/0000-0002-1062-8622)
- Roland Kreis (ORCID: https://orcid.org/0000-0002-8618-6875)
- Thomas Yu (ORCID: https://orcid.org/0000-0002-5841-0198)
- Tobias Kober (ORCID: https://orcid.org/0000-0001-7598-9456)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0272
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00