Immune-mediated indirect interaction between gut microbiota and bacterial pathogens
These findings suggest that while Imd-dependent AMPs may not mediate tripartite interactions in our system, microbiota-host interactions, such as microbiota-mediated immune priming and changes in microbiota load, can shape infection outcomes. These effects on infection outcomes almost certainly exert important selective pressures on the evolution of bacterial virulence.
Authors
- Maryam Keshavarz (ORCID: https://orcid.org/0000-0002-5482-1846)
- Jens Rolff (ORCID: https://orcid.org/0000-0002-1529-5409)
- Mathias Franz (ORCID: https://orcid.org/0000-0001-5111-6503)
- Susan Mbedi (ORCID: https://orcid.org/0000-0002-9633-5045)
- Caroline Zanchi (ORCID: https://orcid.org/0000-0003-4097-9375)
- Sarah Sparmann (ORCID: https://orcid.org/0000-0001-9278-4081)
- Hang Xie (ORCID: https://orcid.org/0000-0001-8318-5554)
Institutions
- Museum für Naturkunde (DE)
- Berlin Center for Genomics in Biodiversity Research (DE)
- Institut für Angewandte Gewässerökologie (Germany) (DE)
- Freie Universität Berlin (DE)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1186/s12915-025-02399-1
- Citations
- 1
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 1.40