Accurate Iron Quantification in Acute Hemorrhagic MI: Alleviating Water Content Sensitivity in Myocardial Edema with Cardiac QSM

Motivation: Hemorrhagic myocardial infarction (hMI) increases the risk of adverse cardiovascular outcomes. Accurate quantification of iron within hMI is critical for improving diagnosis and therapy. Goal(s): However, the coexistence of iron and edema makes reliable iron quantification challenging. A new motion-robust cardiac HDR-QSM technique has been developed to quantify iron in hMI while reducing confounders associated with conventional R2* (1/T2*) methods. Approach: This study investigated the difference between HDR-QSM and R2* in acute and chronic hMI and the influence of myocardial edema on accurate iron quantification. Results: We demonstrated that confounder-corrected cardiac QSM enhances iron sensitivity while reducing edema's confounding impact on hMI. Impact: Cardiac QSM can quantify iron content within hMI, with greater sensitivity and accuracy in the presence of myocardial edema than R2* MRI. HDR-QSM may support reliable iron measurement in studies testing therapies against iron's adverse post-hMI effects.

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Publication Details

Journal
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Published
2025-09-16
DOI
https://doi.org/10.58530/2025/0784
Primary Topic
Atrial Fibrillation Management and Outcomes
Type
article
Field-Weighted Citation Impact
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article

Accurate Iron Quantification in Acute Hemorrhagic MI: Alleviating Water Content Sensitivity in Myocardial Edema with Cardiac QSM

Chia-Chi Yang, Ghazal Yoosefian, Xinqi Li, Xin Liu et al.
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Atrial Fibrillation Management and Outcomes
article

Accurate Iron Quantification in Acute Hemorrhagic MI: Alleviating Water Content Sensitivity in Myocardial Edema with Cardiac QSM

Chia-Chi Yang, Ghazal Yoosefian, Xinqi Li, Xin Liu, Gregory Anthony, Xinheng Zhang, Rohan Dharmakumar, Archana Malagi, Yuheng Huang, Xinliang Guan, Li-Ting Huang, Hsin‐Jung Yang, Debiao Li, Qi Yang, Xiaoming Bi
article en

Abstract

Motivation: Hemorrhagic myocardial infarction (hMI) increases the risk of adverse cardiovascular outcomes. Accurate quantification of iron within hMI is critical for improving diagnosis and therapy. Goal(s): However, the coexistence of iron and edema makes reliable iron quantification challenging. A new motion-robust cardiac HDR-QSM technique has been developed to quantify iron in hMI while reducing confounders associated with conventional R2* (1/T2*) methods. Approach: This study investigated the difference between HDR-QSM and R2* in acute and chronic hMI and the influence of myocardial edema on accurate iron quantification. Results: We demonstrated that confounder-corrected cardiac QSM enhances iron sensitivity while reducing edema's confounding impact on hMI. Impact: Cardiac QSM can quantify iron content within hMI, with greater sensitivity and accuracy in the presence of myocardial edema than R2* MRI. HDR-QSM may support reliable iron measurement in studies testing therapies against iron's adverse post-hMI effects.

Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Openalex Percentile: Top 62%
Atrial Fibrillation Management and Outcomes
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