LUMBER: a Custom 3D Printed Mold Platform for Ex Vivo Sampling of Viable, Clinically Significant Prostate Cancer
Motivation: Currently, no reliable way exists to sample fresh, viable prostate cancer tissue in a clinically localized setting. This hampers basic science research on prostate cancer cell lines. Goal(s): Creation of a 3D mold with needle guides from existing prostate boundary & lesion segmentations to enable harvesting cancer tissue from an explanted prostate without impacting the clinical pathology workflow. Approach: A 3D mold with needle guides was created in Solidworks and then 3D printed. This was used to guide extraction of live cancer tissue via a standard biopsy gun. Results: In 10/10 patients, biopsies performed with the 3D-printed mold yielded prostate tissue with cancer. Impact: Our 3D mold platform enables harvesting live cancer from a prostate that has biopsy-proven, positive MR-targeted lesions and resulted in excellent cancer yield across 10 patients. The design is intuitive for clinicians and does not interfere with clinical pathology workflow.
Authors
- Goran Rac (ORCID: https://orcid.org/0000-0003-4694-1634)
- Guliz Akdas Barkan (ORCID: https://orcid.org/0000-0002-1825-4637)
- Nicholas Lanzotti
- Steven M. Shea (ORCID: https://orcid.org/0000-0002-0360-4884)
- Victor Chen (ORCID: https://orcid.org/0000-0002-5247-3139)
- Gopal Gupta (ORCID: https://orcid.org/0000-0003-4387-9900)
- Maria M. Picken (ORCID: https://orcid.org/0000-0002-8065-6178)
- Jeffrey L. Ellis
- Chaonan Du
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/5160
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00