Perfusion and Time of Exchange Measurements in IDH Mutational Subgroups of Gliomas Using BBB-ASL
Motivation: Unlike contrast-enhanced T1-weighted MRI, which may overlook subtle blood-brain barrier (BBB) integrity changes, the blood-brain barrier arterial spin labeling (BBB-ASL) technique offers a novel non-invasive method to assess BBB disruptions. Goal(s): To analyze the cerebral blood flow (CBF) and exchange time (Tex) differences between the isocitrate dehydrogenase (IDH) mutational subgroups of gliomas using BBB-ASL. Approach: Tex and CBF maps of 25 gliomas were estimated using a region-specific T2-correction within the BBB-ASL model and were compared using a Mann-Whitney U test. Results: IDH-wildtype tumors had significantly higher perfusion than IDH-mutant tumors. Although exchange times were lower in IDH-wildtype tumors, this difference was not significant. Impact: Our findings underscore the promising potential of multi-echo BBB-ASL in evaluating BBB integrity and identifying IDH mutational subgroups of gliomas.
Authors
- Ayça Erşen Danyeli (ORCID: https://orcid.org/0000-0001-8015-9916)
- Alp Di̇nçer (ORCID: https://orcid.org/0000-0001-9158-8353)
- Klaus Eickel (ORCID: https://orcid.org/0000-0002-5700-2029)
- Simon Konstandin (ORCID: https://orcid.org/0000-0002-8143-2221)
- Vera C. Keil (ORCID: https://orcid.org/0000-0001-8699-3506)
- Daniel Hoinkiss (ORCID: https://orcid.org/0000-0002-3358-7296)
- Henk J. M. M. Mutsaerts (ORCID: https://orcid.org/0000-0003-0894-0307)
- Amnah Mahroo (ORCID: https://orcid.org/0009-0005-8480-0965)
- Esin Öztürk-Işık (ORCID: https://orcid.org/0000-0002-8997-878X)
- Koray Özduman (ORCID: https://orcid.org/0000-0002-3543-0401)
- Jan Petr (ORCID: https://orcid.org/0000-0002-3201-6002)
- Beatriz Padrela (ORCID: https://orcid.org/0000-0001-6836-9443)
- Ayşe İrem Çetin (ORCID: https://orcid.org/0000-0002-9298-0565)
- Gülce Turhan (ORCID: https://orcid.org/0000-0003-2645-8442)
- Nora Breutigam
- Matthias Günther (ORCID: https://orcid.org/0000-0002-2650-7956)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0880
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00