Comparison of brain structure and function in adult patients with unilateral versus bilateral asymptomatic moyamoya disease

Motivation: This study aims to investigate whether there are differences in brain structure and function between adults with unilateral and bilateral asymptomatic moyamoya disease (MMD). Goal(s): In asymptomatic MMD patients, the presence of structural and functional differences between unilateral and bilateral involvement may provide evidence for early intervention. Approach: Imaging indicators between the two groups were compared, and the relationship between these indicators and clinical cognition was investigated. Results: Our findings revealed significant differences in perfusion, spontaneous neural activity, and neurovascular coupling between the two groups. Additionally, lower perfusion correlated with cognitive decline. Impact: The decision regarding clinical intervention is complex for certain asymptomatic MMD cases. We investigated the structural and functional abnormalities in adults with unilateral and bilateral asymptomatic MMD, thereby establishing an imaging foundation for the informed selection of clinical interventions.