Visualization of Neurofluids Movement in Mouse Brain Parenchyma by Q-space imaging

Motivation: To elucidate the microscopic movement of neuorfluids in the brain parenchyma for neurowaste clearance. Goal(s): Noninvasive visualization of the neurofluids movement and its pathway in the brain interstitium around white matter fiber. Approach: Q-space imaging was used to measure neurofluids movement along the white matter tracts such as the corpus callosum and fimbria. The movement from the interstitium to the periventricular sinus were also visualized in the neocortex. Results: The regularly aligned movements of water molecules appeared to be observed in the corpus callosum and fimbria. This feature was more well represented in fimbria than in the corpus callosum. Impact: The regular movements of water molecules of a 1-10 μm/s were observed in the corpus callosum and fimbria in the brain parenchyma, indicating that it may be associated with cerebrospinal fluid, which is thought to move along white matter tracts.