Parenchymal CSF mapping (pCSF) from MR T2-relaxometry is associated with PET-measured ventricular CSF clearance (vCSF) in Alzheimer's disease
Motivation: The association between PET-based ventricular (v) CSF clearance (vCSF) and MRI T2 relaxometry-based parenchymal CSF (pCSF) mapping has not been investigated in Alzheimer's disease (AD). Goal(s): To evaluate the correlation between vCSF and pCSF mapping and their associations with amyloid in AD. Approach: Use MR T2 relaxometry-based pCSF mapping and 18F-MK-6240-PET measured vCSF to evaluate their correlation, and their association with 11C-PiB-PET measured amyloid burden. Results: vCSF is more closely associated with pCSF mapping in proximal WM than GM. Both of pCSF and vCSF are associated with amyloid burden and show age and gender differences. Impact: Understanding the brain CSF transport pathway and the association between lateral ventricle CSF turnover rate and brain parenchyma CSF offers insights on the future development of therapeutics for Alzheimer's disease.
Authors
- Gloria Chia-Yi Chiang (ORCID: https://orcid.org/0000-0001-9925-0816)
- Liangdong Zhou (ORCID: https://orcid.org/0000-0002-8389-274X)
- Tom C. Hu (ORCID: https://orcid.org/0000-0002-5824-250X)
- Tracy Butler (ORCID: https://orcid.org/0000-0003-0130-8122)
- Samantha Keil (ORCID: https://orcid.org/0000-0002-7624-7160)
- Mony J. de Leon (ORCID: https://orcid.org/0000-0003-2245-4380)
- Yi Li (ORCID: https://orcid.org/0000-0001-7165-7251)
- Thanh D. Nguyen (ORCID: https://orcid.org/0000-0002-1411-7694)
- Xiuyuan Wang (ORCID: https://orcid.org/0000-0001-6356-3386)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4719
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00