Early Detection of Asymptomatic LVNC: Diagnostic Utility of Non-Contrast T1 Mapping in Routine Screening

Motivation: Early identification of asymptomatic LVNC is essential for timely intervention to prevent complications. Goal(s): To evaluate non-contrast T1 mapping's feasibility for detecting myocardial abnormalities in asymptomatic LVNC patients. Approach: We retrospectively analyzed 64 patients (45 LVNC, 19 controls) with CMR metrics, including T1 mapping and functional parameters, assessed via ROC and correlation analyses. Results: T1 values were significantly elevated in LVNC patients (P = 0.002), showing good diagnostic accuracy (AUC = 0.803), while other parameters were non-significant (all P > 0.05). Impact: Non-contrast T1 mapping effectively detects early myocardial abnormalities in asymptomatic LVNC, allowing precise, routine screening and facilitating early intervention without the need for contrast agents.