Vendor-Agnostic Joint Relaxometry and Myelin Water Fraction Mapping with B1 Correction
Motivation: Obtaining consistent quantitative maps of myelin content and relaxation times across different sites and vendors is crucial for advancing our understanding of brain development. Goal(s): To develop rapid, vendor-agnostic joint T1, T2, and myelin water fraction mapping. Approach: We enhanced the 3D-QALAS method to include an additional T2-preparation module, and improved the AFI technique to rapidly obtain B1+ and B1- maps. We used our dictionary-based fitting and three-compartment modeling for joint mapping. Results: Phantom and in vivo validation confirmed the sensitivity and accuracy of our methods for short T2 values (i.e. myelin) and demonstrated consistency across multiple scanner types. Impact: A vendor-agnostic sequence for joint and rapid acquisition of T1, T2, and myelin water fraction maps was proposed. Along with the harmonized calibration scan, this package could be a valuable tool for multi-site/multi-vendor neuroimaging studies in adult and pediatric populations.
Authors
- Tom Hilbert (ORCID: https://orcid.org/0000-0001-8207-4908)
- Jon‐Fredrik Nielsen (ORCID: https://orcid.org/0000-0002-2058-3579)
- Yohan Jun (ORCID: https://orcid.org/0000-0003-4787-4760)
- Borjan Gagoski (ORCID: https://orcid.org/0000-0003-3777-2621)
- Yogesh Rathi (ORCID: https://orcid.org/0000-0002-9946-2314)
- Maxim Zaitsev (ORCID: https://orcid.org/0000-0001-7530-1228)
- Shohei Fujita (ORCID: https://orcid.org/0000-0003-4276-6226)
- Cemre Arıyürek (ORCID: https://orcid.org/0000-0002-1691-7097)
- Eugene Milshteyn (ORCID: https://orcid.org/0000-0003-0213-7003)
- P. Ellen Grant (ORCID: https://orcid.org/0000-0003-1005-4013)
- Onur Afacan (ORCID: https://orcid.org/0000-0003-2112-3205)
- Berkin Bilgic̦ (ORCID: https://orcid.org/0000-0002-9080-7865)
- Imam Ahmed Shaik (ORCID: https://orcid.org/0009-0000-2849-8849)
- Qiang Liu (ORCID: https://orcid.org/0009-0007-6818-0115)
- Camilo Jaimes
- Gian Piredda
- Antoine Delattre-Klauser
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/1104
- Citations
- 1
- Primary Topic
- Traditional Chinese Medicine Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.38