Repeatability of rapid T1 mapping of brain tissues at 64 mT: a multicenter study
Motivation: Low-field MRI has the potential to improve healthcare worldwide. T1 mapping, a biomarker for brain pathology and development, lacks a rapid and repeatable protocol at low field MRI. Goal(s): Develop and validate a clinically feasible, reproducible T1 mapping protocol at 64 mT, achieving stable measurements across multiple sites. Approach: We implemented a 10-minute T1 mapping protocol on identical low-field MRI systems at six sites, acquiring in vivo (N=60) and phantom data to assess repeatability. Results: The protocol achieved high reproducibility, with inter-site variations below ±3% in phantom, providing repeatable non significantly different T1 values in white and grey matter in N=60 volunteers. Impact: Our multi-site study establishes repeatable T1 mapping in vivo and in phantom at 64 mT in a 10-minute protocol, offering robust, quantitative brain tissue characterization suitable for clinical applications in Point-of-Care settings.
Authors
- Beatrice Lena (ORCID: https://orcid.org/0000-0001-9283-5918)
- Niall Bourke (ORCID: https://orcid.org/0000-0001-6478-1430)
- Todor Karaulanov (ORCID: https://orcid.org/0000-0001-9833-9915)
- Derek Kenton Jones (ORCID: https://orcid.org/0000-0003-4409-8049)
- Shannon Kolind (ORCID: https://orcid.org/0000-0003-1362-1968)
- Rui Teixeira (ORCID: https://orcid.org/0000-0003-0884-2600)
- Andrew Webb (ORCID: https://orcid.org/0000-0001-8042-963X)
- Mara Cercignani (ORCID: https://orcid.org/0000-0002-4550-2456)
- Carly Bennallick
- Samson Lecurieux Lafayette
- James Gholam (ORCID: https://orcid.org/0009-0003-3487-2720)
- Francesco Padormo (ORCID: https://orcid.org/0000-0001-5699-2692)
- Emil Ljungberg (ORCID: https://orcid.org/0000-0003-1456-7967)
- Irene Vavasour
- Steven Williams (ORCID: https://orcid.org/0000-0001-9080-5897)
- Pia C. Sundgren (ORCID: https://orcid.org/0000-0001-9237-1236)
- Joseph V. Hajnal (ORCID: https://orcid.org/0000-0002-2690-5495)
- Sean Deoni (ORCID: https://orcid.org/0000-0002-0633-6328)
- Ruben van den Broek (ORCID: https://orcid.org/0009-0006-4412-9510)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0906
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00