Rapid Whole Brain 180µm Mesoscale In-vivo T2w Imaging

Motivation: Mesoscale MRI can provide intricate details of the brain anatomy. However, increasing the spatial resolution can dramatically reduce SNR while increasing the scan time. Goal(s): We propose to achieve 180μm isotropic resolution T2-weighted imaging on a 7T scanner with significantly reduced acquisition time while preserving high SNR and robustness to motion. Approach: Our approach leverages multi-view thick-slice acquisitions and an enhanced ROVER-MRI algorithm with multi-resolution hash encoding to reconstruct whole-brain isotropic resolution T2w images. Results: We demonstrate the feasibility of acquiring 180 μm in-vivo T2w in ~17 mins (28x smaller voxels than the next best whole brain T2w scan). Impact: ROVER-MRI with multi-resolution hash encoding facilitates efficient and seamless MRI super-resolution reconstruction, achieving rapid 180μm isotropic resolution while reducing scan time. Our method offers a substantial leap in acquiring mesoscale whole-brain T2w imaging with minimal noise and motion artifacts.