Association of gray-white matter junction tissue volume loss with metabolic biomarkers in patients with type 2 diabetes
Motivation: Prior research has primarily focused on overall brain atrophy and white matter hyperintensities. Goal(s): To evaluate the gray-white matter junction tissue volume (gwJTV) damage in Type 2 diabetes mellitus (T2D) patients with and without carotid plaque and its association with several metabolism-related biomarkers. Approach: A cross-sectional study of 69 T2D patients with (36) or without (33) asymptomatic atherosclerosis was conducted by evaluating the metabolic biomarkers and the gwJTV . Results: gwJTV was particularly sensitive to changes in these biomarkers. Higher brain tissue volumes were found in participants without plaque compared to those with plaque. Impact: This study contributes to the field of diabetes and neuroimaging by introducing the concept of gwJTV as a new MRI measure for evaluating brain tissue integrity in T2D patients.
Authors
- Soonchan Park (ORCID: https://orcid.org/0000-0001-6057-7117)
- Geon‐Ho Jahng (ORCID: https://orcid.org/0000-0001-8881-1884)
- In‐Kyung Jeong (ORCID: https://orcid.org/0000-0001-7857-546X)
- Yunan Tian (ORCID: https://orcid.org/0000-0002-7069-2757)
- Chang‐Woo Ryu
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4878
- Primary Topic
- Cardiac Imaging and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00