Detecting dopaminergic degeneration in clinically uncertain parkinsonian syndrome patients using fast MR-STAT relaxometry
Motivation: Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) offers fast T1-/T2-mapping for tissue characterization. We investigated the ability to detect dopaminergic degeneration in clinically uncertain parkinsonian syndrome (CUPS) patients. Goal(s): To assess differences in T1-/T2-values between neurodegenerative and non-neurodegenerative parkinsonism in relevant brain regions using MR-STAT, with dopamine transporter SPECT (DaT-SPECT) as gold standard. Approach: We compared mean T1-/T2-values of grey matter/white matter/caudate nucleus/globus pallidus/putamen/thalamus of patients with neurodegenerative (abnormal DaT-SPECT) versus non-neurodegenerative parkinsonism (normal DaT-SPECT). Results: We found consistently lower T1-values and higher T2-values in neurodegenerative versus non-neurodegenerative CUPS patients, reflecting neuropathological changes in neurodegenerative parkinsonism, indicating potential of MR-STAT as diagnostic tool. Impact: Our results demonstrate that MR-STAT detects differences in T1-/T2-values between neurodegenerative versus non-neurodegenerative parkinsonism patients in a fast and inexpensive way, therewith showing potential as easily accessible tool for detecting neuropathological changes in neurodegenerative parkinsonism with potential diagnostic application.
Authors
- Jeroen Blankevoort
- Martijn Beudel (ORCID: https://orcid.org/0000-0002-2488-7051)
- Miha Fuderer (ORCID: https://orcid.org/0000-0002-5673-915X)
- Cornelis A. T. van den Berg (ORCID: https://orcid.org/0000-0002-5565-6889)
- Henk W. Berendse (ORCID: https://orcid.org/0000-0002-9189-3662)
- Stefano Mandija (ORCID: https://orcid.org/0000-0002-4612-5509)
- Tom van Mierlo
- Alessandro Sbrizzi (ORCID: https://orcid.org/0000-0003-3276-4542)
- Jan Booij (ORCID: https://orcid.org/0000-0001-6378-7638)
- Elsmarieke van de Giessen
- Oscar van der Heide (ORCID: https://orcid.org/0000-0002-8451-525X)
- Hanna Liu
- Rob A. de Bie (ORCID: https://orcid.org/0000-0001-5882-9303)
- Elon Wallert (ORCID: https://orcid.org/0000-0003-0017-1160)
- Martin Bastiaan Schilder (ORCID: https://orcid.org/0009-0003-4058-4928)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4538
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00