Metabolite T1 and T2 Relaxation Times in Healthy Aging
Motivation: Metabolite relaxation measurements vary with age, in patterns that are distinct from changes in water relaxation, presumably reporting on specific cellular microenvironments. Goal(s): To investigate metabolite T1 and T2 relaxation times at 3 T across the lifespan. Approach: T1 and T2 relaxation times of metabolites were measured from an aging cohort consisting of 101 participants. Statistical analyses were conducted to identify correlations between T1/T2 and age, and between T1 and T2 for each metabolite of interest and tissue water. Results: T1 and T2 were correlated in the aging cohort for tNAA2.0, tCr3.0 and Glx in both CSO and PCC. Impact: Understanding the life-course of metabolite relaxation times is a critical pre-requisite to studies of metabolite concentration across the lifespan. We report correlations of T1 and T2 of metabolites with age, and between T1 and T2 in a large aging cohort.
Authors
- Kathleen E. Hupfeld (ORCID: https://orcid.org/0000-0001-5086-4841)
- Gizeaddis Lamesgin Simegn (ORCID: https://orcid.org/0000-0003-1333-4555)
- Helge J. Zöllner (ORCID: https://orcid.org/0000-0002-7148-292X)
- Aaron T. Gudmundson (ORCID: https://orcid.org/0000-0001-5104-0959)
- Georg Oeltzschner (ORCID: https://orcid.org/0000-0003-3083-9811)
- Saipavitra Murali-Manohar
- Dunja Simičić (ORCID: https://orcid.org/0000-0002-6600-2696)
- Richard A.E. Edden (ORCID: https://orcid.org/0000-0002-0671-7374)
- Emily Carter
- Steve C. N. Hui (ORCID: https://orcid.org/0000-0002-1523-4040)
- Eric C. Porges (ORCID: https://orcid.org/0000-0003-3885-5859)
- Yulu Song (ORCID: https://orcid.org/0000-0002-4416-7959)
- Christopher W. Davies‐Jenkins (ORCID: https://orcid.org/0000-0002-6015-762X)
- Vivek Srikar Yedavalli (ORCID: https://orcid.org/0000-0002-2450-4014)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/1247
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00