Quantitative Susceptibility Mapping and R2* of Ischemia-reperfusion Injury and its Relationship with Reactive Oxygen Species Activity
Motivation: There is a need for specific imaging of ischemia-reperfusion injury (IRI) as it initiates infarct iron deposition, catalyzing reactive oxygen species (ROS) production and heart failure. Goal(s): Our goal was to assess and image the relationships between susceptibility, R2*, and ROS activity. Approach: Six swine with IRI were imaged to quantify iron using QSM and R2*, and to measure ROS activity. Results: Regions of hemorrhage and infarct had higher susceptibility, R2* and ROS activity compared to remote regions. There was a positive correlation between infarct ROS activity and R2* in the hemorrhage, and between infarct ROS activity and susceptibility in the hemorrhage. Impact: The observed associations between magnetic susceptibility and R2* with ROS activity allows for better understanding of IRI and potential to develop new targeted interventions. This suggests that iron could be a catalyst for ROS production in ischemia-reperfusion injury.
Authors
- Sophia Swago (ORCID: https://orcid.org/0000-0001-8334-4746)
- Meagan J. McManus (ORCID: https://orcid.org/0000-0001-6064-0665)
- Evan Gallagher (ORCID: https://orcid.org/0000-0003-1548-4960)
- Brianna F. Moon (ORCID: https://orcid.org/0000-0003-0642-0551)
- Robert H. Mach (ORCID: https://orcid.org/0000-0002-7645-2869)
- Chiara Camillo (ORCID: https://orcid.org/0000-0001-8000-3188)
- Walter R T Witschey (ORCID: https://orcid.org/0000-0003-1669-2120)
- Elizabeth Thompson (ORCID: https://orcid.org/0000-0002-1094-8861)
- Giovanni Ferrari (ORCID: https://orcid.org/0000-0002-8863-2496)
- Victor A. Ferrari (ORCID: https://orcid.org/0000-0001-8696-3243)
- Marina Awad
- Estíbaliz Castillero (ORCID: https://orcid.org/0000-0002-2213-5809)
- Cory M. Tschabrunn (ORCID: https://orcid.org/0000-0003-2887-1150)
- Joel S. Karp (ORCID: https://orcid.org/0000-0002-6154-8585)
- Paco E. Bravo (ORCID: https://orcid.org/0000-0002-0022-4376)
- Abhijit Bhattaru (ORCID: https://orcid.org/0000-0002-1383-1992)
- Robert C. Gorman
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/1270
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00