Precise Quantitative Assessment of Hippocampal Subregional Structural Changes Associated with Cerebral Small Vessel Disease

Motivation: This study focuses on exploring the differences in the volume of the hippocampal (Hippocampus, HP) subregions in patients with different loads of cerebral small vessel disease (CSVD). Goal(s): To investigate the relationship between HP subregion volume changes and cognitive-motor function impairment through multivariate statistical analysis, providing a new perspective on the mechanism and prognosis of clinical symptoms of CSVD. Approach: Prospective cohort study Results: The volume reduction of the granular cell layer-molecular layer-dentate gyrus-head (GC-ML-DG-head) subregion of the HP was related to CSVD load, and the change in GC-ML-DG-head volume played a partial mediating role in motor function (TUG) impairment caused by CSVD. Impact: This study provides data on HP subregion volume changes related to CSVD load, providing new evidence for the mechanism of cognitive-motor function impairment in CSVD, and offering the potential for more precise imaging markers.