Plasma Neurofilament Light is associated with less brain tissue, larger ventricles, and higher white matter hyperintensities volume
Motivation: The relation of plasma neurofilament light (NfL), a marker of neuronal damage, with brain characteristics is not well understood. Goal(s): Investigation the relation of NfL with brain morphometry and white matter hyperintensity (WMH) volume in non-demented older adults. Approach: We analyzed NfL, brain morphometry, and WMH volume in 202 community-based older adults. Results: Higher NfL levels were linked to less brain tissue, larger ventricles and higher WMH volume, suggesting NfL's sensitivity to both neurodegenerative and vascular changes. Impact: This study positions NfL as a non-specific marker of age-related brain pathology, supporting its use for broader assessment of brain health in clinical settings.
Authors
- David Alan Bennett (ORCID: https://orcid.org/0000-0003-3689-554X)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0003-0756-5007)
- Gobinda Chowdhury (ORCID: https://orcid.org/0000-0002-2122-9547)
- Konstantinos Arfanakis (ORCID: https://orcid.org/0000-0001-9705-597X)
- Arnold M Evia (ORCID: https://orcid.org/0000-0003-2262-890X)
- Khalid Saifullah
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4856
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00