Impact of Sleep on Extracellular Space in Human Brains: A Simultaneous Study with Sodium MRI and EEG

Motivation: The accumulation of amyloid-beta (Aβ) plaques is a key factor in Alzheimer's Disease pathogenesis. Animal studies indicate that reduced cerebrospinal fluid (CSF) clearance may impair the removal of these neurotoxic proteins by 40-70%, while sleep can double clearance efficiency due to an increase in extracellular space. Goal(s): To determine the impact of sleep on extracellular space in humans. Approach: We investigated changes in extracellular volume fraction (ECVF) across sleep stages using simultaneous sodium MRI and electroencephalography (EEG). Results: A significant decrease in ECVF was observed in gray matter regions of the brain during non-rapid eye movement (NREM) stage 3 sleep. Impact: Our findings confirmed the impact of sleep on extracellular volume fraction in the human brain, which may influence cerebrospinal fluid clearance and has potential implications for Alzheimer's Disease progression.

Authors

Publication Details

Journal
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Published
2025-09-16
DOI
https://doi.org/10.58530/2025/4580
Primary Topic
Sleep and Wakefulness Research
Type
article
Field-Weighted Citation Impact
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article

Impact of Sleep on Extracellular Space in Human Brains: A Simultaneous Study with Sodium MRI and EEG

Arjun V. Masurkar, Yvonne W. Lui, Yulin Ge, Ying‐Chia Lin et al.
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Sleep and Wakefulness Research
article

Impact of Sleep on Extracellular Space in Human Brains: A Simultaneous Study with Sodium MRI and EEG

Arjun V. Masurkar, Yvonne W. Lui, Yulin Ge, Ying‐Chia Lin, Simon Henin, Kathleen T. Watson, Yongxian Qian, J. F. Babb, Anli Liu, Zena Rockowitz, Nahbila‐Malikha Kumbella, Xingye Chen, Justin Quimbo
article en

Abstract

Motivation: The accumulation of amyloid-beta (Aβ) plaques is a key factor in Alzheimer's Disease pathogenesis. Animal studies indicate that reduced cerebrospinal fluid (CSF) clearance may impair the removal of these neurotoxic proteins by 40-70%, while sleep can double clearance efficiency due to an increase in extracellular space. Goal(s): To determine the impact of sleep on extracellular space in humans. Approach: We investigated changes in extracellular volume fraction (ECVF) across sleep stages using simultaneous sodium MRI and electroencephalography (EEG). Results: A significant decrease in ECVF was observed in gray matter regions of the brain during non-rapid eye movement (NREM) stage 3 sleep. Impact: Our findings confirmed the impact of sleep on extracellular volume fraction in the human brain, which may influence cerebrospinal fluid clearance and has potential implications for Alzheimer's Disease progression.

Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Openalex Percentile: Top 75%
Sleep and Wakefulness Research
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Impact of Sleep on Extracellular Space in Human Brains: A Simultaneous Study with Sodium MRI and EEG — Arjun V. Masurkar, Yvonne W. Lui, et al. · Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition (2025) | TGRS Research Map | TGRS