Association of right ventricular structure and function with Heart Failure with reduced and preserved Ejection Fraction: the MESA study

Motivation: The right side of the heart has been less studied compared to the left side in its association with heart failure. Goal(s): To study the association of right ventricular structure and function with incident Heart Failure subtypes. Approach: We assess the association of right ventricular structure and function measured by cardiac magnetic resonance to incident heart failure subtypes in a large multi-ethnic cohort free of cardiovascular disease. Results: In this large cohort study, low right ventricular ejection fraction was predictive of Heart Failure with reduced Ejection Fraction while very high right ventricular ejection fraction was predictive of Heart Failure with preserved Ejection Fraction. Impact: We have identified a subset of individuals with a unique phenotype of supernormal RV ejection fraction that may be at a higher risk of heart failure with preserved ejection fraction.