SORDINO for mapping glymphatic dynamics and choroid plexus efflux

Motivation: This study is motivated by the need for advanced imaging tools to non-invasively map CSF dynamics, essential for understanding neurodegenerative disease mechanisms and developing targeted therapies. Goal(s): This study aims to establish SORDINO as a versatile tool for imaging fluid dynamics in the brain. Approach: Using SORDINO, a silent, motion-resistant T1-sensing sequence with contrast agents (Gd, Mn), we dynamically segmented critical brain regions in preclinical models. Kinetic parameters derived from the Empirical Mathematical Model (EMM) demonstrated SORDINO's effectiveness in capturing fluid kinetics. Results: SORDINO successfully segmented brain regions involved in CSF dynamics, demonstrating precise kinetic profiling and potential for advanced CNS imaging applications. Impact: This study pioneers the use of SORDINO MRI, a silent, distortion-free, motion-insensitive, and efficient T1-sensing sequence, to map glymphatic dynamics or choroid plexus efflux, enabling functional segmentation of brain ventricular spaces and the choroid plexus for studying brain fluid dynamics.