nTMS-Based Tractography Assessment After Brain Tumor Resection: Understanding the Neuroplasticity of the Motor Areas

Motivation: There is limited understanding of neuroplasticity in motor areas after brain tumor resection. The need for better post-surgery assessments of motor function recovery and neuroplastic changes motivated this study. Goal(s): The study aimed to evaluate neuroplastic changes in motor pathways following brain tumor resection using nTMS-guided tractography, with a focus on structural connectivity. Approach: nTMS-guided tractography was used to assess changes in the corticospinal tract (CST) and motor lateralization at 1 and 3 months post-surgery. Results: Significant changes in structural connectivity and motor lateralization were observed in some patients, with increased FA and improved lateralization, suggesting neuroplasticity and motor recovery after tumor resection. Impact: The results could impact brain tumor surgery and rehabilitation, providing insights into post-surgical recovery of motor function. Future research could explore the mechanisms of neuroplasticity, guiding rehabilitation strategies to optimize functional outcomes in patients.