Tissue remodeling after ischemic stroke influences brain biomechanics and can be captured with MR Elastography
Motivation: Tissue regeneration and reorganization following ischemic stroke are of clinical interest, but are not fully assessable with routinely used imaging techniques. Goal(s): Determine if post-ischemic brain tissue changes alter brain biomechanics rendering the quantifiable with MR Elastography. Approach: The MCAO stroke model in C57BL/6 mice was used to longitudinally measure biomechanical properties of infarcted and healthy brain tissue. Imaging metrics were compared to histopathology. Results: Tissue stiffness and phase angle dynamically changed. This was presumably caused by combined kinetics of tissue degradation and reorganization. Impact: MR Elastography reveals dynamic biomechanical changes of infarcted and normal appearing brain tissue following transient ischemia. Thus, MRE can support the characterization of post-ischemic tissue reorganization, providing information occult to clinically established imaging techniques.
Authors
- Giacomo Annio (ORCID: https://orcid.org/0000-0002-0646-635X)
- Reiner Kunze (ORCID: https://orcid.org/0000-0002-8428-1027)
- Tanja Poth (ORCID: https://orcid.org/0009-0001-5612-4622)
- Martin Bendszus (ORCID: https://orcid.org/0000-0002-9094-6769)
- A. Barbier
- Roland Zerelles (ORCID: https://orcid.org/0000-0003-1420-1025)
- Hugo H. Marti (ORCID: https://orcid.org/0000-0002-8456-334X)
- Katharina Schregel (ORCID: https://orcid.org/0000-0003-4367-1667)
- Sabine Heiland (ORCID: https://orcid.org/0000-0002-2796-3451)
- Pinar Kilic
- Manuel Fischer (ORCID: https://orcid.org/0000-0001-7459-1024)
- Volker Sturm (ORCID: https://orcid.org/0000-0001-8681-9372)
- Ralph Sinkus
- S Amin
- Rebecca Zierold
- Maria Harlacher
- Nadine Heselmaier
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0792
- Primary Topic
- Elasticity and Material Modeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00