Myocardial iron deficiency in renal anemia patients on peritoneal dialysis: A cardiac magnetic resonance T2* mapping study

Motivation: Iron deficiency anemia in chronic kidney disease (CKD) increases cardiovascular risk and mortality in peritoneal dialysis (PD) patients. Goal(s): This study evaluated cardiac iron levels using CMR T2* sequences and assessed their predictive capacity for left ventricular dysfunction (LVSD) in PD patients with anemia. Approach: Eighty-three end-stage renal disease (ESRD) patients and 41 controls were included. Standardized CMR imaging was used to analyze correlations between myocardial iron, hemoglobin, and LV function. Results: Anemic patients had higher T2* values, indicating myocardial iron deficiency. This finding was associated with reduced left ventricular ejection fraction, highlighting its significance in LV dysfunction. Impact: Cardiac magnetic resonance T2* mapping is a valuable technique for quantitatively measuring myocardial iron levels, facilitating earlier diagnosis of iron deficiency, and guiding treatment in peritoneal dialysis patients.