Baseline predictors of adipose tissue proton density fat fraction (PDFF) reduction in participants undergoing metabolic bariatric surgery
Motivation: Visceral (VAT) and subcutaneous (SAT) adipose tissue PDFF are correlated to BMI and decrease with weight loss, however the underlying baseline factors associated with these changes have not yet been elucidated. Goal(s): Our goal was to assess baseline predictors for VAT PDFF and SAT PDFF reduction after weight loss. Approach: Baseline characteristics were assessed in participants and compared to changes in VAT and SAT PDFF 12 months after undergoing metabolic bariatric surgery. Results: Participants with healthier metabolic profiles at baseline had more pronounced reductions in VAT and SAT PDFF 12 months after metabolic bariatric surgery. Impact: Adipose tissue PDFF, with further research and validation, could aid as a novel metric in monitoring metabolic health in patients with obesity and during weight loss.
Authors
- David T. Harris (ORCID: https://orcid.org/0000-0001-9850-6234)
- Eduardo L. Grunvald (ORCID: https://orcid.org/0000-0001-9332-7069)
- Walter C. Henderson (ORCID: https://orcid.org/0000-0001-8225-4722)
- Claude B. Sirlin (ORCID: https://orcid.org/0000-0002-6639-9072)
- Ryan C. Broderick (ORCID: https://orcid.org/0000-0002-1821-9989)
- Garth R. Jacobsen
- Anne O. Lidor (ORCID: https://orcid.org/0000-0002-9911-3114)
- Scott B. Reeder (ORCID: https://orcid.org/0000-0003-4728-8171)
- Melissa Silva (ORCID: https://orcid.org/0000-0003-4466-7600)
- Yesenia Covarrubias
- Rashmi Agni (ORCID: https://orcid.org/0000-0001-7803-4647)
- Luke M. Funk (ORCID: https://orcid.org/0000-0003-4475-304X)
- Jeffrey B. Schwimmer (ORCID: https://orcid.org/0000-0001-8538-2877)
- Danielle Batakis
- Vitor F. Martins (ORCID: https://orcid.org/0000-0002-9060-1314)
- Tanya Wolfson
- Jake Weeks
- Ryan Sappenfield
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/2666
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 0.00