Dynamic Reconfiguration of Brain Functional Network in Hemiplegic Stroke

Motivation: Research on dynamic brain network reconstruction in stroke patients remains scarce, limiting our understanding of brain functional remodeling mechanisms. Goal(s): This study aims to investigate the dynamic brain network characteristics of hemiplegic stroke patients through multilayer network reconstruction. Approach: We reconstructed the community of dynamic functional connectivity from resting-state fMRI and compared the modularity (Q value) and switching rates between stroke patients and matched healthy controls. Results: Stroke patients showed significantly higher modularity in brain networks, while the frontoparietal network (FPN) exhibited a significantly lower switching rate, both correlated with clinical symptoms. Impact: This study offers a new perspective on dynamic functional network reconstruction in hemiplegic stroke patients, revealing the connection between brain functional remodeling and motor impairments, thereby offering valuable evidence for guiding future clinical interventions.