Functional connectivity strength in subjective cognitive decline through rs-fMRI on 5T MRI: comparison of single-echo BOLD and multi-echo BOLD

Motivation: Subjective cognitive decline (SCD) is considered to be the best window period for early diagnosis and intervention of Alzheimer's disease. However, the applicability of MBME-BOLD in SCD on 5T remains unclear. Goal(s): To assess the performance and gFCS alterations of MBME-BOLD in SCD on 5T. Approach: MBME-BOLD were used to evaluate tSNR and functional connectivity strength (FCS) alterations in SCD and normal control (NC) on 5T MRI. Results: tSNR was significantly improved, and signal loss was effectively reduced by MBME. gFCS of the parahippocampal gyrus from MBME-BOLD was increased in SCD, and showed significantly positive correlation with ALVT immediate. Impact: This is the first successful attempt for ME-BOLD to small datasets on 5T, in which the increased gFCS of the parahippocampal gyrus has potential to serve as sensitive neuroimaging biomarkers for the preclinical detection of individuals with incipient AD.