Single-Site Experience of Liver Fat and Iron Quantitation with a 2D Flip Angle Modulated CSE-MRI Sequence in the Clinical Setting
Motivation: 2D Flip Angle Modulated (FAM) CSE-MRI is a novel, free-breathing fat and iron quantitation sequence that still needs to be validated in the clinical setting. Goal(s): To compare the IQ and quantitative metrics of free-breathing 2D FAM CSE-MRI and breath-held 3D CSE-MRI in the clinical setting at a single site. Approach: 79 patients were scanned with both 2D FAM and 3D CSE-MRI sequences. A trained radiologist assessed the IQ/apparent SNR/artifacts/PDFF/R2* values for each of the two sequences. Results: 2D FAM CSE-MRI showed improved IQ, apparent SNR, and fewer artifacts compared to the 3D CSE-MRI, while showing no statistically significant difference in PDFF/R2* values. Impact: With its free-breathing nature and reproducible PDFF and R2* values compared to gold standard 3D CSE-MRI, 2D FAM CSE-MRI shows promise as a routine tool in clinical liver fat and iron quantitation.
Authors
- Mukesh G. Harisinghani (ORCID: https://orcid.org/0000-0003-0993-1947)
- Arnaud Guidon (ORCID: https://orcid.org/0000-0001-6777-1633)
- Diego Hernando (ORCID: https://orcid.org/0000-0002-0016-0317)
- Jiayi Tang (ORCID: https://orcid.org/0009-0000-8565-6575)
- Scott B. Reeder (ORCID: https://orcid.org/0000-0003-4728-8171)
- Eugene Milshteyn (ORCID: https://orcid.org/0000-0003-0213-7003)
- Amirkasra Mojtahed (ORCID: https://orcid.org/0000-0003-1879-9255)
- Nabih Nakrour (ORCID: https://orcid.org/0009-0000-6402-7585)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/2834
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00