Diagnosing Intramyocardial Hemorrhage using Free-Breathing, Cardiac QSM with Full LV Coverage: Clinical Findings with Validations in Canines
Motivation: Accurate detection and quantification of intramyocardial hemorrhage (IMH) in reperfused myocardial infarction (MI) is crucial for patient management. Goal(s): However, current standard IMH imaging techniques (e.g., breath-hold T2* or 3D R2* maps) pose multiple technical challenges with imaging artifacts and confounders. Approach: This study presents a free-breathing cardiac high-dynamic-range quantitative susceptibility mapping (HDR-QSM) technique to improve IMH detection and quantification over conventional iron-sensitive MRI. Results: Proposed method is tested in animal models and MI patients, which show that HDR-QSM can significantly reduce imaging artifacts, improve accuracy in detection of hMI and quantification of iron quantification within hMI compared to existing standards. Impact: The free-breathing HDR-QSM technique enhances IMH detection and quantification over R2* mapping. It is validated in animals and tested in STEMI patients with impaired breath-holding ability and shows promise for broader clinical use, pending further validation in larger trials.
Authors
- Chia-Chi Yang (ORCID: https://orcid.org/0000-0003-0933-7067)
- Ghazal Yoosefian
- Xinqi Li (ORCID: https://orcid.org/0009-0002-4799-8333)
- Fei Han (ORCID: https://orcid.org/0000-0001-5363-7556)
- Xiaoming Bi (ORCID: https://orcid.org/0000-0001-6286-9172)
- Xin Liu (ORCID: https://orcid.org/0000-0002-7529-3149)
- Gregory Anthony (ORCID: https://orcid.org/0000-0002-7032-6538)
- Chang Gao (ORCID: https://orcid.org/0000-0003-3597-1360)
- Kim-Lien Nguyen
- Qi Yang (ORCID: https://orcid.org/0000-0002-5773-0456)
- Xinheng Zhang (ORCID: https://orcid.org/0000-0001-6409-3160)
- Rohan Dharmakumar (ORCID: https://orcid.org/0000-0003-4120-4635)
- Archana Malagi (ORCID: https://orcid.org/0000-0002-2332-170X)
- Yuheng Huang (ORCID: https://orcid.org/0000-0002-5358-4826)
- Xinliang Guan (ORCID: https://orcid.org/0000-0001-9634-5537)
- Li-Ting Huang (ORCID: https://orcid.org/0000-0001-5616-0431)
- Hsin-Jung Yang
- Debiao Li (ORCID: https://orcid.org/0000-0001-8560-8231)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0423
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 0.00