Age-related variations in T1/T2 ratios and perfusion in the deep gray matter nuclei: An MRI study of healthy individuals
Motivation: It remains unclear about MRI signal intensity (i.e. T1/T2 ratio) and perfusion changes during aging, and the relationship between T1/T2 ratio and perfusion in deep gray matter nuclei (DGMN). Goal(s): Systematically exploring the changes of T1/T2 ratio, CBF and ATT during aging and the intensity-perfusion relationship in DGMN. Approach: T1 and T2-weighted and ASL imaging data from 657 healthy adults in the HCP-Aging dataset were used to analyze the changes of T1/T2 ratios, CBF and ATT during aging, and the intensity-perfusion relationship in DGMN. Results: T1/T2 ratio and CBF decreased with age. ATT increased with age. Lower T1/T2 ratios correlated with increased CBF. Impact: Using a large cohort dataset, our study revealed the changes of signal intensity and cerebral perfusion during aging, which may enhance the understanding of the underlying tissue and vascular changes during aging.
Authors
- Yulin Ge (ORCID: https://orcid.org/0000-0002-2320-6031)
- Jiangyang Zhang (ORCID: https://orcid.org/0000-0003-0740-2662)
- Miaoqi Zhang (ORCID: https://orcid.org/0000-0003-4119-4940)
- Chao Wang (ORCID: https://orcid.org/0000-0002-5268-9570)
- Chenyang Li (ORCID: https://orcid.org/0000-0003-4244-8615)
- Zhe Sun (ORCID: https://orcid.org/0000-0002-6043-8675)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/3778
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00