Free Water mediates the association between glymphatic dysfunction and executive function performance
Motivation: To explore biomarkers for cSVD related VCID Goal(s): To examine the associations between the ALPS index and executive function performance and the potential mediation effect of free water on such association. Approach: Four independent cohorts with racial and ethnic diversities were examined. Then the association between ALPS index and UDS3-EF scores and the mediation effect of free water were evaluated. Results: ALPS index exhibited positive association with UDS3-EF scores and the free water mediated such association. Impact: Our findings provide a strong clinical rationale for the use of the ALPS index as a marker of cSVD-related VCID.
Authors
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Steven Cen (ORCID: https://orcid.org/0000-0002-7859-8909)
- Mohamad Habes (ORCID: https://orcid.org/0000-0001-9447-5805)
- Joel H. Kramer (ORCID: https://orcid.org/0000-0002-2917-8297)
- Lara Stables
- Arvind Caprihan (ORCID: https://orcid.org/0000-0002-4810-359X)
- Xingfeng Shao (ORCID: https://orcid.org/0000-0002-4130-6204)
- Giuseppe Barisano (ORCID: https://orcid.org/0000-0001-5598-1369)
- Kay Jann (ORCID: https://orcid.org/0000-0003-3574-0538)
- Konstantinos Arfanakis (ORCID: https://orcid.org/0000-0001-9705-597X)
- Pauline Maillard (ORCID: https://orcid.org/0000-0003-3516-6345)
- Steven Mark Greenberg (ORCID: https://orcid.org/0000-0003-1792-8887)
- Danny J.J. Wang (ORCID: https://orcid.org/0000-0002-0840-7062)
- Brent Andrew Gold
- Charles DeCarli (ORCID: https://orcid.org/0000-0003-1914-2693)
- Herpreet Singh (ORCID: https://orcid.org/0000-0003-3797-7301)
- John M. Ringman (ORCID: https://orcid.org/0000-0001-5429-0777)
- Xiaodan Liu (ORCID: https://orcid.org/0000-0001-9112-1032)
- Claudia Liliana Satizábal (ORCID: https://orcid.org/0000-0002-1115-4430)
- Hanzhang Lu
- Karl Helmer
- Alexa S. Beiser
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4359
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00