Quantitative evaluation of neurocutaneous melanosis using 3D MR fingerprinting
Motivation: To quantitatively evaluate neurocutaneous melanosis (NCM) abnormalities using T1- and T2-relaxation times from 3D MR fingerprinting (MRF). Goal(s): To develop a novel tool for evaluating NCM lesions on 3D MRF. Approach: Regions of interests (ROIs) were manually placed on the amygdala and other melanosis lesions, including the cerebellum and thalamus, on T1- and T2-mappings from MRF and then on T1-weighted imaging (T1WI). For normalization, T1 intensity ratios to the middle cerebellar peduncles were calculated on T1WI. Results: Melanosis-positive areas had significantly lower T1 min values, indicating that the minimum T1 value threshold for detecting melanosis may be approximately 1000 ms. Impact: This study introduces a quantitative MR fingerprinting method for assessing neurocutaneous melanosis (NCM), improving diagnostic accuracy and objectivity, and supporting early, precise identification of melanosis, which may enhance understanding and management of NCM.
Authors
- Sachi Okuchi (ORCID: https://orcid.org/0000-0002-0831-195X)
- Michiharu Sakamoto (ORCID: https://orcid.org/0000-0002-0024-6807)
- Sayo Otani (ORCID: https://orcid.org/0000-0002-3187-0207)
- Takayuki Yamamoto (ORCID: https://orcid.org/0000-0003-3553-3272)
- Satoshi Nakajima (ORCID: https://orcid.org/0000-0001-5088-4017)
- Masaki Umehana
- Naoki Morimoto (ORCID: https://orcid.org/0000-0002-0712-3172)
- Yasutaka Fushimi (ORCID: https://orcid.org/0000-0002-1982-3168)
- Satoshi Ikeda (ORCID: https://orcid.org/0000-0001-5203-7911)
- Takeshi Yoshida (ORCID: https://orcid.org/0000-0003-0992-064X)
- Yongping Ma
- Shuichi Ito (ORCID: https://orcid.org/0000-0002-5242-8987)
- Akihiko Sakata (ORCID: https://orcid.org/0000-0002-3647-7877)
- Yuji Nakamoto
- Shin Morooka
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0862
- Primary Topic
- Cutaneous Melanoma Detection and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00