Ultra-small iron oxide nanoparticles for diagnosing deep vein thrombosis in T1-weighted magnetic resonance imaging

Motivation: Deep vein thrombosis (DVT) has been one of the leading causes of sudden death. However, the lack of clinically available venous-specific magnetic resonance contrast agents makes it difficult to diagnose. Goal(s): Design and synthesis of a vein-specific magnetic resonance contrast agent for deep vein thrombosis imaging has become an urgent clinical need. Approach: In this study, we synthesized a novel type of ultra-small iron oxide nanoparticles, utilizing the property of nanoparticles being difficult to extravasate to achieve resonance imaging of venous vessels. Results: The results demonstrate that ultra-small iron oxide can diagnose deep venous thrombosis of the lower extremities. Impact: Ultra-small iron oxide improves clinical deep vein thrombosis detection, addressing venous contrast agent deficiencies and advancing MRI use in clinical settings.