Quantification of Amyloid in the Piriform Cortex in Alzheimer’s and Parkinson’s Disease using PET-MR
Motivation: Olfactory dysfunction may be an early indicator of Alzheimer's disease (AD), but it remains unclear whether amyloid pathology in AD affects the primary olfactory piriform cortex. Goal(s): To compare piriform cortex uptake to the adjacent medial temporal lobe across the progression of AD pathology using amyloid and tau PET-MR. Approach: Using 18F-Florbetaben/PI-2620 PET-MR, we computed piriform and medial temporal amyloid/tau uptake in AD, mild cognitive impairment, amyloid negative/positive controls, and Parkinson's disease (PD). Results: Piriform amyloid was positively associated with increasing disease status. Amyloid and tau uptake were positively correlated, while amyloid and memory scores were negatively correlated. Impact: We show amyloid uptake in the piriform cortex as well as other medial temporal regions, including the entorhinal-perirhinal cortices. These results further enrich the scientific understanding of the role of the piriform cortex in the progression of early AD.
Authors
- Michael Zeineh (ORCID: https://orcid.org/0000-0002-6940-9096)
- Marios Georgiadis (ORCID: https://orcid.org/0000-0003-0733-4559)
- Mahta Karimpoor (ORCID: https://orcid.org/0000-0001-8025-6230)
- Eric van Staalduinen
- America Romero
- Anthony D. Wagner (ORCID: https://orcid.org/0000-0003-0624-4543)
- Guido Davidzon (ORCID: https://orcid.org/0000-0001-5579-6825)
- Jarrett Rosenberg (ORCID: https://orcid.org/0000-0003-2706-3290)
- Maya Yutsis
- Kathleen L. Poston (ORCID: https://orcid.org/0000-0003-3424-7143)
- Mackenzie Carlson (ORCID: https://orcid.org/0000-0002-0857-3116)
- Greg Zaharchuk (ORCID: https://orcid.org/0000-0001-5781-8848)
- Hossein Moein Taghavi (ORCID: https://orcid.org/0000-0002-8585-1634)
- Alexandra N. Trelle (ORCID: https://orcid.org/0000-0003-2837-8753)
- Elizabeth C. Mormino (ORCID: https://orcid.org/0000-0002-4542-6537)
- Christina B. Young (ORCID: https://orcid.org/0000-0001-9535-2137)
- Victor W. Henderson (ORCID: https://orcid.org/0000-0003-1198-9240)
- Hillary Vossler
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/3003
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00