A nomogram based on clinical factors and gadobenate dimeglumine‑enhanced MRI for prediction of GPC‑3 expression in hepatocellular carcinoma

Motivation: The expression level of Glypican-3 (GPC-3) is closely associated with the malignancy and prognosis of HCC. Goal(s): To investigate the predictive value of a nomogram based on clinical factors and gadobenate dimeglumine-enhanced MRI for predicting the expression of GPC-3 in HCC. Approach: The preoperative clinical data,gadobenate dimeglumine-enhanced MRI features and pathological GPC-3 expression of 185 HCC patients were retrospectively collected.Nomogram model for predicting GPC-3 expression in patients was established. Results: Significant differences in AFP,intratumoral hemorrhage,and TLR-HBP were found between GPC-3 positive and negative HCC groups.The nomogram model integrating clinical and MRI parameters demonstrated superior predictive performance for GPC-3 expression compared to individual indicators. Impact: Early noninvasive prediction of GPC-3 expression provides guidance for prognosis assessment and tumor treatment. A nomogram based on clinical and gadobenate dimeglumine-enhanced MRI can effectively predict GPC-3 expression in HCC,helping clinicians evaluate prognosis and select appropriate treatments for HCC patients.