MRI study of the optic nerve in the first whole eye and face transplant patient
Motivation: 46-year-old male with catastrophic face injury and left globe loss received the first whole eye and face transplant. Our study targets postoperative changes to the affected Optic Nerve (ON). Goal(s): We aimed to probe the neural structure and function of the ON with MRI. Approach: Over 18 months, we acquired a series of diffusion and functional MRI. We then applied tissue microstructure modeling to monitor longitudinal changes along the ON. Results: DTI and NODDI models identified optic neuropathy and axonal swelling. No functional connectivity from the transplanted globe to the visual cortex was confirmed. Impact: This preliminary study demonstrates plausibility and reproducibility of probing postoperative changes to the transplanted ON noninvasively with MRI.
Authors
- Patryk Filipiak
- Steven H. Baete (ORCID: https://orcid.org/0000-0003-3361-3789)
- Evan G. Stein (ORCID: https://orcid.org/0000-0002-1260-4907)
- Kamri Clarke (ORCID: https://orcid.org/0009-0005-9310-5876)
- Yvonne W. Lui (ORCID: https://orcid.org/0000-0002-9984-9164)
- Mary T. Bruno (ORCID: https://orcid.org/0000-0003-1625-0293)
- Vaidehi S. Dedania
- Alay Shah (ORCID: https://orcid.org/0009-0008-2311-4138)
- Sachin Chinta
- David L. Tran (ORCID: https://orcid.org/0000-0002-8732-9436)
- Daniel J. Ceradini (ORCID: https://orcid.org/0000-0002-0901-7445)
- Zakia Ben Youss
- Eduardo Rodríguez
- Omnia Hassanin
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/3876
- Primary Topic
- Organ and Tissue Transplantation Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00