Development of a multi-parameter MRI phantom with adjustable T1, T2 and ADC properties

Motivation: Phantoms are essential in MRI for quality control and technique validation, but typically lack the ability to replicate multiple MRI parameters simultaneously. Goal(s): To investigate substances for adjusting T1, T2 and ADC values to mimic biological tissues. Approach: Phantoms were prepared using Gd-DTPA, agarose and soy lecithin to adjust T1, T2 and ADC values. The samples were then evaluated for accuracy and stability using relaxometry and DWI. Results: The designed phantoms showed a good agreement between target and measured values for T1, T2 and ADC. Impact: The use of Gd-DTPA, agarose, and soy lecithin allows for precise, independent adjustment of T1, T2, and ADC values in phantoms, providing a versatile approach to simulating multiple tissue characteristics in MRI studies.