Water Relaxation Atlas for Age- and Region-Specific Metabolite Correction in the Osprey MRS Analysis Workflow
Motivation: Current MRS water-referenced metabolite quantification uses fixed literature relaxation values, despite known age and regional variability. This causes inaccuracies, especially in aging studies, highlighting the need for age- and region-specific T1 and T2 values for accurate quantification. Goal(s): To develop a water relaxometry atlas with region- and age-specific T1 and T2 values integrated into the Osprey analysis workflow for improved MRS quantification. Approach: 101 participants were scanned to create the atlas, which was integrated into Osprey for age-and region-specific corrections. Results: The atlas revealed significant T1 and T2 variations across age and brain regions and was successfully incorporated into Osprey for improved accuracy. Impact: Integrating the age- and region-specific water relaxometry atlas into Osprey improves MRS metabolite quantification, particularly in aging studies, by reducing biases in water-referenced corrections.
Authors
- Kathleen E. Hupfeld (ORCID: https://orcid.org/0000-0001-5086-4841)
- Helge J. Zöllner (ORCID: https://orcid.org/0000-0002-7148-292X)
- Aaron T. Gudmundson (ORCID: https://orcid.org/0000-0001-5104-0959)
- Dunja Simičić (ORCID: https://orcid.org/0000-0002-6600-2696)
- Richard A.E. Edden (ORCID: https://orcid.org/0000-0002-0671-7374)
- Emily Carter
- Steve C. N. Hui (ORCID: https://orcid.org/0000-0002-1523-4040)
- Saipavitra Murali‐Manohar (ORCID: https://orcid.org/0000-0002-4978-0736)
- Douglas Dean (ORCID: https://orcid.org/0000-0002-7057-1285)
- Can Ceritoglu (ORCID: https://orcid.org/0000-0001-6081-2551)
- Eric C. Porges (ORCID: https://orcid.org/0000-0003-3885-5859)
- Yulu Song (ORCID: https://orcid.org/0000-0002-4416-7959)
- Christopher W. Davies‐Jenkins (ORCID: https://orcid.org/0000-0002-6015-762X)
- J. Tilak Ratnanather (ORCID: https://orcid.org/0000-0002-8631-489X)
- Gizeaddis Simegn
- Georg Oeltzschner
- Emlyn Muska
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4467
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00