Hippocampal volume alteration in patients with cognitive impairment due to post-COVID-19 condition.
Motivation: Assessing brain alterations in post-COVID-19 condition (PCC) can enhance our understanding of the underlying mechanisms driving neurocognitive impairment in this condition. Hippocampal alterations are often related to cognitive impairment, and previous studies have linked these alterations to PCC. Goal(s): To conduct an exploratory analysis of potential hippocampal volumetric alterations in patients experiencing cognitive impairment due to PCC. Approach: Comparison of brain volumetric data from Freesurfer Hippocampal Subfield segmentation of patients with PCC to that of healthy controls (HC). Results: Patients with PCC show reduced bilateral hippocampal volume in most regions of the hippocampal body compared to the HC group. Impact: Understanding the biological changes associated with PCC advances the identification of underlying mechanisms and could guide the development of effective treatments for this condition.
Authors
- Andrea Dell’Orco (ORCID: https://orcid.org/0000-0002-3964-8360)
- Mirja Steinbrenner (ORCID: https://orcid.org/0000-0001-5425-4709)
- Michael Scheel (ORCID: https://orcid.org/0000-0002-3505-2914)
- Lucas C. Adam (ORCID: https://orcid.org/0000-0001-9067-1710)
- Christiana Franke (ORCID: https://orcid.org/0000-0002-5609-2472)
- David Steinbart (ORCID: https://orcid.org/0000-0002-6952-430X)
- Lorenz Pechstein
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/3930
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 0.00