Cerebral change of the fractional amplitude of low frequency fluctuation (fALFF) in a harmaline-induced tremor rat model

Motivation: While the harmaline-induced tremor rat model is based on cerebellar circuitry, its impact on the cerebrum remains unknown. Goal(s): Assess the cerebral activity in harmaline-induced rat tremor model. Approach: Resting-state fMRI scan of the harmaline-administered SD rat. Results: Comparing to control, increased fALFF in prefrontal area, cingulate cortex, restrosplenial cortex, and motor area was found in the harmaline-induced tremor rat. Such results indicate that, in addition to the tremor cerebellar circuit and motor function, harmaline can also alter the resting-state activity in other key brain regions. Impact: This study shows the fALFF changes in the cerebrum of the harmaline-induced tremor rat model, providing the first insight into the brain activity of cerebral area in addition to classical tremor cerebellar circuit.