Transverse relaxation of metabolites from birth across the lifespan
Motivation: There is an urgent need to gather location-specific and age-resolved reference data to support MRS quantification of HBCD, the largest MRS study ever. Goal(s): To measure metabolite transverse relaxation times T2 of thalamus in a lifespan cohort. Approach: Metabolite T2s were measured in a cohort of 28 participants aged from 0 to 64 years old. PRESS-localized TE-series spectra in bilateral thalamus were linear combination modeled and T2 estimated from exponential modeling of metabolite coefficients. Results: There was a significant shortening of T2 with age for the four major singlets, tNAA2.0, tCr3.0, tCr3.9 and tCho. Impact: Current practice in MRS quantification is to ignore well-known effects of brain-region and subject age on relaxation times. Location-specific and age-resolved T2 reference values are a pre-requisite for accurate quantification of metabolite concentrations with MRS.
Authors
- Abdelrahman Gamil Gad (ORCID: https://orcid.org/0000-0002-4461-3517)
- Gizeaddis Lamesgin Simegn (ORCID: https://orcid.org/0000-0003-1333-4555)
- Helge J. Zöllner (ORCID: https://orcid.org/0000-0002-7148-292X)
- Georg Oeltzschner (ORCID: https://orcid.org/0000-0003-3083-9811)
- Richard A.E. Edden (ORCID: https://orcid.org/0000-0002-0671-7374)
- Mary Beth Nebel (ORCID: https://orcid.org/0000-0003-0185-3382)
- Saipavitra Murali‐Manohar (ORCID: https://orcid.org/0000-0002-4978-0736)
- Cristian Navarro
- Yulu Song (ORCID: https://orcid.org/0000-0002-4416-7959)
- Christopher W. Davies‐Jenkins (ORCID: https://orcid.org/0000-0002-6015-762X)
- Vivek Srikar Yedavalli (ORCID: https://orcid.org/0000-0002-2450-4014)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4473
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00