Choroid plexus and perivascular space enlargement in Alzheimer's disease: a 7T MRI study

Motivation: Glymphatic dysfunction is implicated in Alzheimer's disease (AD) through the accumulation of neurotoxic substances. Goal(s): This study aims to investigate the association between choroid plexus volume (CPV), perivascular spaces (PVS), and cognitive function in AD using 7T MRI. Approach: Using ultra-high-field 7T MRI, we performed segmentation and volume measurements of PVS and CPV in AD patients and healthy controls, analyzing their relationship with cognitive scores. Results: The study identified a significant enlargement of PVS in AD, and though not statistically significant, an association between enlarged CPV and reduced cognitive scores was observed. Impact: This study suggests that CPV and enlarged PVS may serve as new non-invasive MRI marker for glymphatic dysfunction in AD.