Exploring the Link between Cerebral Small Vessel Disease and Alzheimer’s Disease with [11C]CS1P1, a Novel PET Tracer of Neuroinflammation
Motivation: This study investigates the use of [11C]CS1P1 PET imaging to assess neuroinflammation as an early biomarker of cerebral small vessel disease (cSVD) and Alzheimer's Disease (AD). Goal(s): The goal of this study is to assess whether [11C]CS1P1 uptake correlates with cSVD or AD burden. Approach: The overall approach of this study is a prospective cross-sectional analysis correlating [11C]CS1P1 to white matter hyperintensity (WMH) burden and PiB Centiloid. Results: Among 23 participants, results showed a correlation between WMH burden and [11C]CS1P1 PET uptake in both normal appearing white matter and gray matter, suggesting its utility in identifying high-risk areas for disease progression. Impact: [11C]CS1P1 PET could be a biomarker of early AD and cSVD. This imaging approach could guide the timely application of disease-modifying therapies and possibly enhancing treatment outcomes.
Authors
- Tammie L.S. Benzinger (ORCID: https://orcid.org/0000-0002-8114-0552)
- Karl A. Friedrichsen (ORCID: https://orcid.org/0000-0002-9233-1418)
- Andria L. Ford (ORCID: https://orcid.org/0000-0003-0605-8943)
- Y Wang (ORCID: https://orcid.org/0009-0006-1706-2867)
- Inema Orukari
- Yasheng Chen (ORCID: https://orcid.org/0000-0002-1133-452X)
- Matthew R. Brier (ORCID: https://orcid.org/0000-0001-5987-8705)
- Zhude Tu (ORCID: https://orcid.org/0000-0003-0325-835X)
- Hongyu An (ORCID: https://orcid.org/0000-0001-6459-2269)
- Shaney Flores (ORCID: https://orcid.org/0000-0003-2726-8704)
- Jayashree Rajamanickam
- Bo Wang (ORCID: https://orcid.org/0000-0002-1192-0668)
- Jin‐Moo Lee (ORCID: https://orcid.org/0000-0001-5895-0277)
- Lynne C. Jones (ORCID: https://orcid.org/0000-0002-6135-5564)
- Ying Hwey Nai
- Farzaneh Rahmani
- Jude‐Patrick Nnamdi Okafor
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/1056
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00