Deep-ERx2: Deep Learning Reconstruction for fast high-resolution non-Cartesian Compressed-Sensing MR Spectroscopic Imaging at 3T and 7T
Motivation: High-Resolution magnetic resonance spectroscopic imaging (MRSI) is a powerful, non-invasive method for detailed imaging of brain metabolism. However, traditional methods for reconstructing accelerated high-resolution whole-brain MRSI are time-consuming, posing challenges for its routine clinical application. Goal(s): Reconstruction of high-resolution whole-brain MRSI acquired at 3T and 7T in a timely fashion. Approach: Deep-learning reconstruction using recurring interlaced convolutional layers with joint dual-space feature representation for non-Cartesian Compressed-Sensing MRSI acquired by 3D ECCENTRIC sampling. Results: Deep learning ECCENTRIC reconstruction (Deep-ER) speeds up 600 times the reconstruction of high-resolution ECCENTRIC (k,t) data. Deep-learning reconstruction provides improved SNR metabolic maps across acceleration factors. Impact: Deep-ER enables high-resolution (3.4 mm isotropic) metabolic imaging with clinically feasible acquisition (4-9 min) and reconstruction times (1 min) at 3T and 7T. These times are compatible with the clinical workflow.
Authors
- Gülnur Ungan (ORCID: https://orcid.org/0000-0002-5436-4665)
- Daniel P. Cahill (ORCID: https://orcid.org/0000-0003-2552-6546)
- Wolfgang Bogner (ORCID: https://orcid.org/0000-0002-0130-3463)
- Stanislav Motyka (ORCID: https://orcid.org/0000-0002-6314-316X)
- Paul Weiser (ORCID: https://orcid.org/0009-0004-2503-5696)
- Jörg Dietrich (ORCID: https://orcid.org/0000-0001-8291-0136)
- Bernhard Strasser (ORCID: https://orcid.org/0000-0001-9542-3855)
- Ovidiu C. Andronesi (ORCID: https://orcid.org/0000-0002-7412-0641)
- Erik J. Uhlmann (ORCID: https://orcid.org/0000-0003-1432-4754)
- Georg Langs
- Tracy T. Batchelor (ORCID: https://orcid.org/0000-0001-7568-6607)
- Antoine Klauser (ORCID: https://orcid.org/0000-0003-3019-9914)
- Polina Golland (ORCID: https://orcid.org/0000-0003-2516-731X)
- Malte Hoffmann (ORCID: https://orcid.org/0000-0002-5511-0739)
- Nalini Singh (ORCID: https://orcid.org/0000-0003-3584-2198)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4606
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00