Simultaneous Dynamic Sodium (23Na) MRI and EEG Analysis of Cerebrospinal Fluid Flow Velocity in the Human Brain During Sleep
Motivation: Alzheimer's disease involves neurotoxic amyloid-beta (Aβ) plaques. In mice, impaired CSF clearance reduces Aβ removal by 70%. Sleep may boost CSF clearance by expanding extracellular space, potentially affecting CSF flow velocity. Goal(s): The impact of sleep on CSF flow in humans remains unclear due to limited non-invasive imaging. Approach: Using sodium (23Na) MRI, we measured extracellular volume in 29 healthy brains, with sleep stages monitored via MRI-compatible EEG. Results: We observed significant differences in CSF flow velocity between gray matter (GM) and white matter (WM) during sleep stages W, N2, and N3, though no clear velocity trends across stages were found. Impact: This work may clarify sleep's role in Aβ clearance in humans.
Authors
- Arjun V. Masurkar (ORCID: https://orcid.org/0000-0002-2498-2059)
- Yvonne W. Lui (ORCID: https://orcid.org/0000-0002-9984-9164)
- Yulin Ge (ORCID: https://orcid.org/0000-0002-2320-6031)
- Ying‐Chia Lin (ORCID: https://orcid.org/0000-0001-7243-0980)
- Simon Henin (ORCID: https://orcid.org/0000-0003-0997-3266)
- Yongxian Qian (ORCID: https://orcid.org/0000-0002-9931-7790)
- Anli Liu (ORCID: https://orcid.org/0000-0002-1118-981X)
- Nahbila‐Malikha Kumbella
- Xingye Chen
- Katrina J R Watson
- Justin Quimbo
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/5047
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00